Concepedia

Macrocyclisation of small peptides enabled by oxetane incorporation

Stefan Roesner, George J. Saunders, Ina Wilkening, Eleanor Jayawant, Joanna V. Geden, Paul Kerby, Ann M. Dixon, Rebecca Notman, Michael Shipman

Chemical Science · 2019 · 44 citations · 30 references

DOIFull text

Open access

Concepts

Abstract

values in the presence or absence of an oxetane at the glycine residue, indicating that bioactivity is fully retained upon amide C[double bond, length as m-dash]O bond replacement.

References

30

GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers

M Abraham, Teemu J. Murtola, Roland Schulz et al. · SoftwareX · 2015 · 26.8K citations · Full text

, , +11

NMR with Proteins and Nucleic Acids

Kurt Wüthrich · Europhysics news · 1986 · 8K citations

, , +12

Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

Wadih Arap, Renata Pasqualini, Erkki Ruoslahti · Science · 1998 · 2.1K citations

, , +17

Encyclopedia of computational chemistry

Choice Reviews Online · 1999 · 1.1K citations

, , +12

Macrocycles: lessons from the distant past, recent developments, and future directions

Andrei K. Yudin · Chemical Science · 2014 · 488 citations · Full text

, , +12