2‐Alkynylaryl Aldehydes (Enynals) in Organic Synthesis

Abstract

Abstract 2‐Alkynylaryl aldehydes are widely used in organic reactions. Their great success is rooted in their multiple functional groups. This review will focus on five kinds of triggered mechanisms: (i) aldehydes as electrophiles, (ii) alkynes as electrophiles, (iii) 5‐ exo ‐ dig reactions, (iv) 6‐ endo ‐ dig intermediates, and (v) imine intermediates via 6‐ endo ‐ dig cyclizations. Reactions with alkenes, alkynes, arenes, malononitrile, alcohols, amines, amides, acetal, ketones, hydrazine, iodobenzene, azides, carbenes, arylboronic acids, amino acids etc. will be discussed. We hope that this review will pronote future research in this area. magnified image