Concepedia

A Novel Preservation Solution Containing a JNK Inhibitory Peptide Efficiently Improves Islet Yield for Porcine Islet Isolation

Hirofumi Noguchi, Chika Miyagi‐Shiohira, Yoshiki Nakashima, Nana Ebi, Eri Hamada, Yoshihito Tamaki, Kazuho Kuwae, Shinji Kitamura, Naoya Kobayashi, Issei Saitoh,

Transplantation · 2018 · 12 citations · 30 references

DOI

Abstract

Advantages of EJ solution over UW solution were inhibition of JNK activity and reduced collagenase inhibition. EJ solution may therefore be more suitable for islet isolation than UW solution.

References

30

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

A.M. James Shapiro, Jonathan R.T. Lakey, Edmond A. Ryan et al. · New England Journal of Medicine · 2000 · 5.2K citations · Full text

A central role for JNK in obesity and insulin resistance

Jiro Hirosumi, Gürol Tuncman, Lufen Chang et al. · Nature · 2002 · 3.3K citations

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Automated Method for Isolation of Human Pancreatic Islets

Camillo Ricordi, Paul E. Lacy, EDWARD H. FINKE et al. · Diabetes · 1988 · 1.3K citations

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

Bernhard J. Hering, William R. Clarke, Nancy D. Bridges et al. · Diabetes Care · 2016 · 629 citations · Full text

Islet isolation assessment in man and large animals

Camillo Ricordi, Derek W. R. Gray, Bernhard J. Hering et al. · Acta Diabetologica · 1990 · 576 citations

, , +5