Infection and Immunity · 2018 · 23 citations · 39 references
Life SciencesImmunologyMicrobiologyAdaptive ImmunityHost-pathogen InteractionsInnate ImmunityHost Defense Against InfectionImmune Evasion By PathogensImmune Responses To InfectionInnate Immune ResponseInnate Immune Signaling PathwaysMajor Histocompatibility ComplexAntigen Presenting CellsBacterial Immune Evasion MechanismsImmune Response To Bacterial InfectionInnate Immunity PathwaysMajor Histocompatibility Complex Class I PresentationMajor Histocompatibility Complex Class I RecognitionPathogen-host Interaction TargetingScrub Typhus
Orientia tsutsugamushi is an obligate intracellular bacterium that infects mononuclear and endothelial cells to cause the emerging global health threat scrub typhus. The ability of O. tsutsugamushi to survive in monocytes facilitates bacterial dissemination to endothelial cells, which can subsequently lead to several potentially fatal sequelae.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
PubMed · 1997 · 66.6K citations
Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines
Joseph D. Miller, Robbert van der Most, Rama Akondy et al. · Immunity · 2008 · 613 citations · Full text