Concepedia

CD44 Assists the Topical Anti-Psoriatic Efficacy of Curcumin-Loaded Hyaluronan-Modified Ethosomes: A New Strategy for Clustering Drug in Inflammatory Skin

Yongtai Zhang, Qing Xia, Yanyan Li, Zehui He, Zhe Li, Teng Guo, Zhonghua Wu, Nianping Feng

Theranostics · 2018 · 212 citations · 36 references

DOIFull text

Open access

Concepts

Abstract

We demonstrated increased topical drug delivery of curcumin to inflamed tissues using HA-ES targeting the highly expressed CD44 protein. This innovative strategy could be applied for the development of topical drug delivery systems targeting inflamed skin.

References

36

Analyzing real-time PCR data by the comparative CT method

Thomas D. Schmittgen, Kenneth J. Livak · Nature Protocols · 2008 · 26.7K citations

, , +3

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

Leslie van der Fits, Sabine Mourits, Jane S.A. Voerman et al. · The Journal of Immunology · 2009 · 2.1K citations · Full text

, , +17

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

Seth B. Coffelt, Kelly Kersten, Chris W. Doornebal et al. · Nature · 2015 · 1.7K citations · Full text

, , +14

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

Caroline E. Sutton, Stephen J. Lalor, Cheryl Sweeney et al. · Immunity · 2009 · 1.5K citations · Full text

, , +16

Ethosomes — novel vesicular carriers for enhanced delivery: characterization and skin penetration properties

Elka Touítou, N. Dayan, L.D. Bergelson et al. · Journal of Controlled Release · 2000 · 1.3K citations

, , +16