Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer, Clifford S. Deutschman, Christopher W. Seymour et al. · JAMA · 2016 · 28K citations · Full text

Veterinary Medicine, Immunology, Pathobiology +17

Actual incidence of global left ventricular hypokinesia in adult septic shock

Antoine Vieillard‐Baron, Vincent Caille, Cyril Charron et al. · Critical Care Medicine · 2008 · 569 citations

Medicine, Cardiology, Critical Care Cardiology +14

LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection

Hua Yuan, Cynthia N. Perry, Chengqun Huang et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2008 · 263 citations · Full text

Life Sciences, Cardiology, Physiology +13

AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis

Dong Liu, Zhiqiang Ma, Shouyin Di et al. · Free Radical Biology and Medicine · 2018 · 228 citations

Life Sciences, Biochemistry, Pharmacology +17

Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through <scp>SIRT1</scp>

Gnanapragasam Arunachalam, Samson Mathews Samuel, Isra Marei et al. · British Journal of Pharmacology · 2013 · 218 citations · Full text

Medicine, Endocrinology, Pharmacology +15