Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through <scp>SIRT1</scp>

Abstract

HG-induced down-regulation of SIRT1 played a crucial role in diabetes-induced endothelial senescence. Furthermore, the protective effect of metformin against HG-induced endothelial dysfunction was partly due to its effects on SIRT1 expression and/or activity.