Preventing murine transfusion‐related acute lung injury by expansion of CD4+CD25+FoxP3+ Tregs using IL‐2/anti‐IL‐2 complexes

Abstract

This study validates that the protective mechanisms against TRALI involve CD4+ CD25+ FoxP3+ Tregs, which can be expanded in vivo by IL-2 and IL-2c. This results in increased IL-10 levels and decreased IL-17A, thereby prophylactically preventing antibody-mediated murine TRALI.

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