Cell Reports · 2018 · 24 citations · 44 references
AgriculturePlant BiologyPlant SciencesPlant BiochemistryPlant Molecular BiologyPlant-microbe InteractionsPlant Defense ResponsesPlant Disease ResistancePlant Immune ResponsesPlant Immune SignalingPlant PathogenesisPlant-pathogen InteractionsEffector Recognition By Host PlantsNucleotide-binding Leucine-rich Repeat ReceptorsPathogen Detection ReceptorsPlant Defense ActivationPlant Pathogen EffectorsPlant Resistance Signaling PathwaysSh3 DomainsVacuolar Protein Targeting
in Nicotiana benthamiana supports the requirement of ESCRT-associated functions for this CC-NLR-activated immunity. Meanwhile, loss of ESCRT function in A. thaliana is lethal, and we find that AMSH3 knockout-triggered seedling lethality is "enhanced disease susceptibility 1" (EDS1) dependent. Future studies may reveal whether AMSH3 is monitored by a TIR-NLR immunity receptor.
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