Concepedia

Sh3 Domains

SH3 Domain is a type of protein interaction domain that belongs to the structural domain class and specifically mediates protein–protein interactions by recognizing and binding to proline-rich motifs in target proteins.

2K

Publications

171.1K

Citations

8.2K

Authors

1.6K

Institutions

Publications per year

2017–2026

178

Parents

Publications

2K

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

Christine Koch, Deborah H. Anderson, Michael F. Moran et al. · Science · 1991 · 1.9K citations

, , +17

Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs

John C. Obenauer · Nucleic Acids Research · 2003 · 1.6K citations · Full text

, , +17

The importance of being proline: the interaction of proline‐rich motifs in signaling proteins with their cognate domains

Brian K. Kay, Michael P. Williamson, Marius Sudol · The FASEB Journal · 2000 · 1.2K citations

, , +17

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

Ruibao Ren, Bruce J. Mayer, Piera Cicchetti et al. · Science · 1993 · 1.2K citations

, , +16

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

Maria Rozakis-Adcock, Ross T. Fernley, John D. Wade et al. · Nature · 1993 · 1K citations

, , +17

1–5 of 2K

Authors

8.2K

  1. BJ
    Bruce J. Mayer

    UConn Health, United States

    26 publications · 4.9K citations

    23

    h-index

  2. LE
    Lewis E. Kay

    University of Toronto, Canada

    26 publications · 2.9K citations

    23

    h-index

  3. HH
    Hidesaburô Hanafusa

    Rockefeller University, United States

    25 publications · 2.6K citations

    22

    h-index

  4. TE
    Thomas E. Smithgall

    University of Pittsburgh, United States

    27 publications · 1.5K citations

    22

    h-index

  5. KS
    Kalle Saksela

    University of Helsinki, Finland

    25 publications · 2.2K citations

    20

    h-index

1–5 of 8.2K

Institutions

1.6K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    61 h-index

    299 publications

    54.8K citations

  2. Harvard University

    Cambridge, United States

    56 h-index

    301 publications

    36.2K citations

  3. University of Toronto

    Toronto, Canada

    51 h-index

    387 publications

    40.9K citations

  4. Rockefeller University

    New York, United States

    43 h-index

    200 publications

    35.2K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    37 h-index

    295 publications

    13.6K citations

  6. National Institutes of Health

    Bethesda, United States

    36 h-index

    160 publications

    18.5K citations

  7. The University of Tokyo

    Tokyo, Japan

    35 h-index

    165 publications

    17.6K citations

  8. Inserm

    Paris, France

    33 h-index

    223 publications

    13.7K citations

1–8 of 1.6K

Venues

  1. Journal of Biological Chemistry

    JBC · 335 publications · 31.1K citations

    106

    h-index

  2. Molecular and Cellular Biology

    MCB · 136 publications · 14.2K citations

    74

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 95 publications · 16.3K citations

    63

    h-index

  4. Journal of Molecular Biology

    JMB · 68 publications · 4.2K citations

    42

    h-index

  5. Biochemistry

    85 publications · 5.2K citations

    41

    h-index

1–5