Stem Cell Reports · 2018 · 61 citations · 40 references
MedicineCancer BiologyOncologyCarcinogenesisMolecular OncologyOncogenesCancer BiomarkersCancer Cell SignalingCancer ProgressionColorectal CancerMolecular Tumor ProfilingSignal Transduction In CancerColorectal Cancer PrognosisMicrorna In CancerMicrorna Regulation In CancerNeoadjuvant ChemoradiationNeoadjuvant ChemoradiotherapyRadiotherapy ResistanceTherapeutic Response PredictionTumor Initiating Cells
Chemo-/radiotherapy resistance is the main cause accounting for most treatment failure in colorectal cancer (CRC). Tumor-initiating cells (TICs) are the culprit leading to CRC chemo-/radiotherapy resistance. The underlying regulation mechanism of TICs in CRC remains unclear. Here we discovered that miR-15b expression positively correlated with therapeutic outcome in CRC. Expression of miR-15b in pretreatment biopsy tissue samples predicted tumor regression grade (TRG) in rectal cancer patients after receiving neoadjuvant radiotherapy (nRT). Expression of miR-15b in post-nRT tissue samples was associated with therapeutic outcome. DCLK1 was identified as the direct target gene for miR-15b and its suppression was associated with self-renewal and tumorigenic properties of DCLK1+ TICs. We identified B lymphoma Mo-MLV insertion region l homolog (BMI1) as a downstream target regulated by miR-15b/DCLK1 signaling. Thus, miR-15b may serve as a valuable marker for prognosis and therapeutic outcome prediction. DCLK1 could be a potential therapeutic target to overcome chemo-/radioresistance in CRC.
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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Darren A.E. Cross, Dario R. Alessi, Philip Cohen et al. · Nature · 1995 · 5.2K citations
Colorectal cancer statistics, 2014
Rebecca L. Siegel, Carol DeSantis, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2014 · 2.6K citations · Full text