Concepedia

Synthesis and biological evaluation against <i>Leishmania donovani</i> of novel hybrid molecules containing indazole-based 2-pyrone scaffolds

Mohamed El Ghozlani, Latifa Bouissane, Mohamed Berkani, Souad Mojahidi, Avekananda Reddy Allam, Carmen Menéndez, Sandrine Cojean, Philippe M. Loiseau, Michel Baltas, El Mostapha Rakib

MedChemComm · 2018 · 12 citations · 14 references

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Concepts

Abstract

values of 2.48 ± 1.02 μM and 2.25 ± 1.89 μM, respectively. However, the cytotoxicity of the most promising compound justifies further pharmacomodulations.

References

14

Discovery of 5-[[4-[(2,3-Dimethyl-2<i>H</i>-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor

Philip A. Harris, Amogh Boloor, Mui Cheung et al. · Journal of Medicinal Chemistry · 2008 · 345 citations · Full text

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Natural and synthetic 2H-pyran-2-ones and their versatility in organic synthesis

Atul Goel, Vishnu Ji Ram · Tetrahedron · 2009 · 293 citations

, , +13

2-Pyrones possessing antimicrobial and cytotoxic activities

Ian J. S. Fairlamb, Lester R. Marrison, Julia M. Dickinson et al. · Bioorganic & Medicinal Chemistry · 2004 · 181 citations

, , +1

5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists

Kevin G. Liu, Albert J. Robichaud, Ronald C. Bernotas et al. · Journal of Medicinal Chemistry · 2010 · 67 citations · Full text

, , +12

Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents

Najat Abbassi, Hakima Chicha, El Mostapha Rakib et al. · European Journal of Medicinal Chemistry · 2012 · 62 citations

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