Concepedia

Hypermethylated in cancer 1 (HIC1) suppresses bladder cancer progression by targeting yes‐associated protein (YAP) pathway

Xiaoguang Zhou, Peng Zhang, Hu Han, Hongen Lei, Xiaodong Zhang

Journal of Cellular Biochemistry · 2018 · 12 citations · 29 references

DOI

Abstract

Our data unprecedently showed that HIC1 was responsible for the inhibition of proliferation, migration, and invasion of BCa via the YAP signaling pathway. These findings suggested that therapeutic strategies regulating HIC1 expression might provide effective treatments for BCa.

References

29

Radical Cystectomy in the Treatment of Invasive Bladder Cancer: Long-Term Results in 1,054 Patients

John P. Stein, Gary Lieskovsky, Susan Groshen et al. · Journal of Clinical Oncology · 2001 · 3.5K citations

TEAD mediates YAP-dependent gene induction and growth control

Bin Zhao, Xin Ye, Jindan Yu et al. · Genes & Development · 2008 · 2.5K citations · Full text

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Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses

Wenyong Chen, David H. Wang, Ray-Whay Chiu Yen et al. · Cell · 2005 · 642 citations · Full text

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ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

Olga Tornavaca, Minghao Chia, Neil Dufton et al. · The Journal of Cell Biology · 2015 · 556 citations · Full text

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

Michele Makos Wales, Margaret A. Biel, Wafik S. El‐Deiry et al. · Nature Medicine · 1995 · 423 citations

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