Mathematical models of DNA methylation dynamics: Implications for health and ageing

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Life Sciences, Genetics, Molecular Biology +17

A general method for numerically simulating the stochastic time evolution of coupled chemical reactions

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DNA Modification Mechanisms and Gene Activity During Development

R. Holliday, J. E. Pugh · Science · 1975 · 1.9K citations

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Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

M F Kane, Massimo Loda, Gretchen M. Gaida et al. · PubMed · 1997 · 1.5K citations

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Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

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