Design, synthesis and evaluation of N2,N4-diaminoquinazoline based inhibitors of phosphodiesterase type 5

Thousands of chemical starting points for antimalarial lead identification

Francisco‐Javier Gamo, Laura M. Sanz, Jaume Vidal et al. · Nature · 2010 · 997 citations

Hit Identification, Medicine, Malaria +8

Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

B.-J. Sung, Kwang Yeon Hwang, Young Ho Jeon et al. · Nature · 2003 · 270 citations

Molecular Pharmacology, Catalytic Domain, Human Phosphodiesterase 5 +10

Sustained efficacy and tolerability of vardenafil, a highly potent selective phosphodiesterase type 5 inhibitor, in men with erectile dysfunction: results of a randomized, double-blind, 26-week placebo-controlled pivotal trial

Wayne J.G. Hellstrom, Marc Gittelman, Gary Karlin et al. · Urology · 2003 · 148 citations

Urology, Andrology, Erectile Dysfunction +4

Synthesis of quinoline derivatives: Discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease

Jole Fiorito, Faisal Saeed, Hong Zhang et al. · European Journal of Medicinal Chemistry · 2012 · 107 citations · Full text

Medicinal Chemistry, Selective Phosphodiesterase 5, Derivative (Chemistry) +8

Antibacterial Activity of a Series of <i>N</i>²,<i>N</i>⁴-Disubstituted Quinazoline-2,4-diamines

Kurt S. Van Horn, Whittney N. Burda, Renee M. Fleeman et al. · Journal of Medicinal Chemistry · 2014 · 97 citations

Bioorganic Chemistry, Antibacterial Activity, Antimicrobial Chemotherapy +17