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Synthesis of quinoline derivatives: Discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease

Jole Fiorito, Faisal Saeed, Hong Zhang, Agnieszka Staniszewski, Feng Yan, Yitshak I. Francis, S. R. Rao, Devarshi M. Thakkar, Shi‐Xian Deng, Donald W. Landry,

European Journal of Medicinal Chemistry · 2012 · 107 citations · 31 references

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31

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva et al. · Nature · 2002 · 4.2K citations

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Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Ganesh M. Shankar, Shaomin Li, Tapan Mehta et al. · Nature Medicine · 2008 · 3.6K citations · Full text

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mouse brain in stereotaxic coordinates

Keith B.J. Franklin, George Paxinos · 1997 · 3.1K citations

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Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

James Cleary, Dominic M. Walsh, J. Hofmeister et al. · Nature Neuroscience · 2004 · 1.7K citations

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Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling

Ottavio V. Vitolo, A. Santangelo, Vincenzo Costanzo et al. · Proceedings of the National Academy of Sciences · 2002 · 522 citations · Full text