Synthesis of quinoline derivatives: Discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease

Jole Fiorito, Faisal Saeed, Hong Zhang, +8

European Journal of Medicinal Chemistry

Medicinal ChemistrySelective Phosphodiesterase 5Derivative (Chemistry)BiochemistryMedicine +6

The diagnostic yield of superior mesenteric angiography: correlation with the pattern of gastrointestinal bleeding.

Jole Fiorito, Lawrence J. Brandt, Orest Kozicky, +2

PubMed

Gastrointestinal BleedingVascular ImageSuperior Mesenteric AngiographyAbdominal ImagingGastroenterology +12

Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

Erica Acquarone, Elentina K. Argyrousi, Manon van den Berg, +10

Molecular Neurodegeneration

Identification of a Novel 1,2,3,4-Tetrahydrobenzo[<i>b</i>][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s Disease

Jole Fiorito, Jérémie Vendôme, Faisal Saeed, +6

Journal of Medicinal Chemistry

PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease

Andrew F. Teich, Mikako Sakurai, Mitesh Patel, +4

Journal of Alzheimer s Disease

Neurochemical BiomarkersPde5 InhibitorsNeurologyNeuropathologyNeuroimmunology +14

Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells

Melania Olivieri, Emanuele Amata, Shila Vinciguerra, +11

Journal of Medicinal Chemistry

Ocular DiseaseImmunologyMolecular PharmacologyAngiogenesisNovel Prodrug +15

Haloperidol metabolite II prodrug: Asymmetric synthesis and biological evaluation on rat C6 glioma cells

Piera Sozio, Jole Fiorito, Viviana di Giacomo, +9

European Journal of Medicinal Chemistry

BiochemistryMedicineAsymmetric SynthesisPharmacological AgentPharmacotherapy +5

Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells

Agostino Marrazzo, Jole Fiorito, Laura Zappalà, +6

European Journal of Medicinal Chemistry

BiochemistryAntiproliferative ActivityMedicineProstate Cancer CellsSecondary Metabolite +5

Pseudo-obstruction associated with colonic ischemia: successful management with colonoscopic decompression.

Jole Fiorito, Robert E. Schoen, L J Brandt

PubMed

Colonic IschemiaBowel WallColorectal SurgeryGastroenterologyEus-guided Gastroenterostomy +6

MRJF4, a novel histone deacetylase inhibitor, induces p21 mediated autophagy in PC3 prostate cancer cells.

Viviana di Giacomo, Valentina Di Valerio, Monica Rapino, +7

PubMed

Tumor BiologyCell AutophagyAutophagy ActivationMmp9 ProteinApoptosis +13