Concepedia

Maternal High Fat Diet Alters Gut Microbiota of Offspring and Exacerbates DSS-Induced Colitis in Adulthood

Runxiang Xie, Yue Sun, Jingyi Wu, Shumin Huang, Ge Jin, Zixuan Guo, Yujie Zhang, Tianyu Liu, Xiang Liu, Xiaocang Cao,

Frontiers in Immunology · 2018 · 118 citations · 48 references

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Abstract

Our data reveal that MHFD in early life can inhibit intestinal development, induce dysbiosis and low-grade inflammation and lead to the disruption of intestinal mucosal barrier in offspring, and enhance DSS-induced colitis in adulthood.

References

48

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

Maria Gloria Domínguez-Bello, Elizabeth K. Costello, Mónica Contreras et al. · Proceedings of the National Academy of Sciences · 2010 · 4.7K citations · Full text

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The Placenta Harbors a Unique Microbiome

Kjersti M. Aagaard, Jun Ma, Kathleen M. Antony et al. · Science Translational Medicine · 2014 · 2.4K citations · Full text

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High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

Kyung‐Ah Kim, Wan Gu, In‐Ah Lee et al. · PLoS ONE · 2012 · 1.2K citations · Full text

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Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring

Shelly A. Buffington, Gonzalo Viana Di Prisco, Thomas A. Auchtung et al. · Cell · 2016 · 1.2K citations · Full text

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Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid

María Carmen Collado, Samuli Rautava, Juhani Aakko et al. · Scientific Reports · 2016 · 1.1K citations · Full text

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