Concepedia

Dclk1 Inhibition Cancels 5-FU-induced Cell-cycle Arrest and Decreases Cell Survival in Colorectal Cancer

Yuki Suehiro, Yoshihiro Takemoto, Arata Nishimoto, Koji Ueno, Bungo Shirasawa, Toshiki Tanaka, Naruji Kugimiya, Atsushi Suga, Eijiro Harada, Kimikazu Hamano

Anticancer Research · 2018 · 27 citations · 20 references

DOIFull text

Open access

Abstract

These results indicate that a combination of 5-FU and LRRK may be an effective, novel approach for colorectal cancer therapy.

References

20

Global cancer statistics

Ahmedin Jemal, Freddie Bray · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text

Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer

Aimery de Gramont, Arié Figer, Michel Seymour et al. · Journal of Clinical Oncology · 2000 · 3.8K citations

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

J-Y Douillard, David Cunningham, AD Roth et al. · The Lancet · 2000 · 3.3K citations

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Action of 2',2'-difluorodeoxycytidine on DNA synthesis.

Peng Huang, Sherri Chubb, Larry W. Hertel et al. · PubMed · 1991 · 884 citations

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Dclk1 distinguishes between tumor and normal stem cells in the intestine

Yuki Nakanishi, Hiroshi Seno, Ayumi Fukuoka et al. · Nature Genetics · 2012 · 407 citations

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