Larry W. Hertel

Action of 2',2'-difluorodeoxycytidine on DNA synthesis.

Peng Huang, Sherri Chubb, Larry W. Hertel et al. · PubMed · 1991 · 884 citations

Nucleic Acid Chemistry, Bioorganic Chemistry, Biochemistry +9

Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine).

Larry W. Hertel, G B Boder, Julian S. Kroin et al. · PubMed · 1990 · 683 citations

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Chemistry +14

Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine.

Volker Heinemann, Larry W. Hertel, Gerald B. Grindey et al. · PubMed · 1988 · 509 citations

Hematological Malignancy, Medicinal Chemistry, Chemoprevention Strategy +15

Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine.

Volker Heinemann, Yi-Zheng Xu, Sherri Chubb et al. · Molecular Pharmacology · 1990 · 405 citations

Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation.

Volker Heinemann, Yi-Zheng Xu, Sherri Chubb et al. · PubMed · 1992 · 330 citations

Cell Death, Cell Culture, Dfdctp Elimination +19