Concepedia

Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease

Silke Nuber, Molly M. Rajsombath, Georgia Minakaki, Jürgen Winkler, Christian P. Müller, Maria Ericsson, Barbara J. Caldarone, Ulf Dettmer, Dennis J. Selkoe

Neuron · 2018 · 141 citations · 59 references

DOI

Concepts

References

59

α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

Jacqueline Burré, Manu Sharma, Theodoros Tsetsenis et al. · Science · 2010 · 1.8K citations · Full text

, , +17

Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

W. Sean Davidson, Ana Jonas, David F. Clayton et al. · Journal of Biological Chemistry · 1998 · 1.6K citations · Full text

, , +17

In vivo demonstration that α-synuclein oligomers are toxic

Beate Winner, Roberto Jappelli, Samir K. Maji et al. · Proceedings of the National Academy of Sciences · 2011 · 1.5K citations · Full text

, , +17

Phosphorylation of Ser-129 Is the Dominant Pathological Modification of α-Synuclein in Familial and Sporadic Lewy Body Disease

John P. Anderson, Donald E. Walker, Jason Goldstein et al. · Journal of Biological Chemistry · 2006 · 1.4K citations · Full text

, , +17

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

Tim Bartels, Joanna G. Choi, Dennis J. Selkoe · Nature · 2011 · 1.2K citations · Full text

, , +12