Postprandial lipid absorption in seven heterozygous carriers of deleterious variants of MTTP in two abetalipoproteinemic families

Analysis of serial measurements in medical research.

J. N. S. Matthews, D G Altman, Michael J. Campbell et al. · BMJ · 1990 · 3.2K citations · Full text

Public Health, Biostatistics, Clinical Sciences +13

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9

Jonathan C. Cohen, Alexander Pertsemlidis, Ingrid K. Kotowski et al. · Nature Genetics · 2005 · 1.4K citations

Life Sciences, Genetics, Molecular Genetics +13

Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation

Dawei Zhang, Thomas A. Lagace, Rita Garuti et al. · Journal of Biological Chemistry · 2007 · 784 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Absence of Microsomal Triglyceride Transfer Protein in Individuals with Abetalipoproteinemia

John R. Wetterau, Lawrence P. Aggerbeck, Marie-Elisabeth Bouma et al. · Science · 1992 · 759 citations

Life Sciences, Biochemistry, Molecular Biology +14

Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study

Marina Cuchel, Emma A. Meagher, Hendrik du Toit Theron et al. · The Lancet · 2012 · 740 citations · Full text

Life Sciences, Pharmacokinetics, Pharmacology +12