Proceedings of the National Academy of Sciences · 2018 · 57 citations · 40 references
Life SciencesGeneticsMolecular BiologyGene ExpressionGene RegulationTranscriptional RegulationMediator ComplexPromoter RegulationRna-protein InteractionsTranscription FactorsTranscriptional ControlTranscriptional Regulation In EukaryotesNrf2 Pathway ActivationNrf2 Signaling PathwayPathological ScienceRna Sequencing (Rna-seq)Transcriptional ActivationTranscriptional Activator RecruitmentTranscriptional Repression MechanismsTranscriptional Repressor Complexes
Significance Our findings shift the paradigm of NRF2 as a transcriptional activator to one in which NRF2 can also act as a transcriptional repressor, which we believe will stimulate new research areas and interests among scientists from other fields. While the majority of the data provided in this paper center on suppression of MYLK expression and the resulting pathological significance, the more far-reaching findings are the in silico and RNA-seq datasets indicating that the NRF2-replication protein A1 (RPA1)-ARE-NRE complex transcriptionally represses other genes as well, again highlighting the broad scope and significance of NRF2 repression of target genes.
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