Conjugation to Ascorbic Acid Enhances Brain Availability of Losartan Carboxylic Acid and Protects Against Parkinsonism in Rats

Neuroinflammation, oxidative stress, and the pathogenesis of Parkinson’s disease

R. Lee Mosley, Eric J. Benner, Irena Kadiu et al. · Clinical Neuroscience Research · 2006 · 389 citations · Full text

Life Sciences, Neurology, Neuroscience +14

Amyloid β-Protein Is Degraded by Cellular Angiotensin-converting Enzyme (ACE) and Elevated by an ACE Inhibitor

Matthew L. Hemming, Dennis J. Selkoe · Journal of Biological Chemistry · 2005 · 336 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression

Tina Chabrashvili, Chagriya Kitiyakara, Jonathan Blau et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2003 · 325 citations

Life Sciences, Biochemistry, Pharmacology +16

Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily members.

Ralph A. Stearns, Probir Chakravarty, R Chen et al. · Drug Metabolism and Disposition · 1995 · 208 citations

Medicine, Biochemistry, Pharmacology +17

Cognitive Deficit in Amyloid-β–Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-γ Activation

Kana Tsukuda, Masaki Mogi, Jun Iwanami et al. · Hypertension · 2009 · 189 citations · Full text

Medicine, Neuroscience, Pharmacology +17