G1 is the major <i>APOL1</i> risk allele for hypertension-attributed nephropathy in Central Africa

Abstract

The results of this study demonstrate the association of high-risk <i>APOL1</i> genotypes with kidney disease in Kinshasa. The absence of G2/G2 may be consistent with powerful selective sweeps induced by <i>Trypanosoma brucei gambiense</i> infection. In contrast, the presence of <i>APOL1</i> G2/G2 among individuals of African ancestry in the USA may indicate relaxation of natural selection in a trypanosome-free environment.