Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation

Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease

Andreas Weihofen, Kathleen L. Binns, Marius K. Lemberg et al. · Science · 2002 · 526 citations

Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38

Xiaochun Bai, Dongzhu Ma, Anling Liu et al. · Science · 2007 · 381 citations

Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

Michiko Shirane, Keiichi I. Nakayama · Nature Cell Biology · 2002 · 307 citations

Inhibits Apoptosis, Mitochondrial Function, Biochemistry +7

Requirements for Signal Peptide Peptidase-Catalyzed Intramembrane Proteolysis

Marius K. Lemberg, Bruno Martoglio · Molecular Cell · 2002 · 242 citations · Full text

Biochemistry, Natural Sciences, Peptoid +2

Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44

Daizo Murakami, Isamu Okamoto, Osamu Nagano et al. · Oncogene · 2003 · 148 citations

Presenilin-dependent γ-Secretase Activity, Protein Secretion, Signal Transduction +9