<i>Neisseria gonorrhoeae</i> Exposed to Sublethal Levels of Hydrogen Peroxide Mounts a Complex Transcriptional Response

Abstract

The strict human pathogen Neisseria gonorrhoeae is the only causative agent of the sexually transmitted disease gonorrhea. This bacterium encounters hydrogen peroxide produced from host cells during infection, but the organism survives in the presence of this antimicrobial agent. This work shows that the bacterium responds to hydrogen peroxide by regulating the expression of many genes involved in multiple processes.