Emergence and Within-Host Genetic Evolution of Methicillin-Resistant <i>Staphylococcus aureus</i> Resistant to Linezolid in a Cystic Fibrosis Patient

Abstract

copies, associated with lower MICs (8 to 32 mg/liter) and low to moderate generation time increases. Despite these differences, whole-genome sequencing allowed us to determine that all isolates, including the susceptible one isolated before LZD treatment, belonged to the same lineage. In conclusion, LZD resistance can emerge rapidly in CF patients and persist without linezolid selective pressure in colonizing MRSA strains belonging to the same lineage.