Concepedia

Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity

Minoru Ubukata, Ikuo MITANI, Yuichi Nakagawa, Katsuya Maeda, Hiroto Imai, Yosuke Ogoshi, Takahiro Hotta, Shohei Sakata, Ryuhei Sano, Hisayo Morinaga,

European Journal of Medicinal Chemistry · 2018 · 30 citations · 17 references

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Concepts

References

17

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

Peter Ertl, Bernhard Rohde, Paul M. Selzer · Journal of Medicinal Chemistry · 2000 · 3K citations

, , +15

Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity

James M. Ntambi, Makoto Miyazaki, Jonathan P. Stoehr et al. · Proceedings of the National Academy of Sciences · 2002 · 1.1K citations · Full text

, , +17

Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol

James M. Ntambi · Journal of Lipid Research · 1999 · 770 citations · Full text

, , +17

Ligand efficiency indices as guideposts for drug discovery

C ABADZAPATERO · Drug Discovery Today · 2005 · 523 citations

, , +14

Hepatic Stearoyl-CoA Desaturase-1 Deficiency Protects Mice from Carbohydrate-Induced Adiposity and Hepatic Steatosis

Makoto Miyazaki, Matthew T. Flowers, Harini Sampath et al. · Cell Metabolism · 2007 · 427 citations · Full text

, , +14