VEGF heparinized-decellularized adipose tissue scaffolds enhance tissue engineering vascularization <i>in vitro</i>

Song Mei, Zhou Yu, Yi Liu

RSC Advances · 2018 · 18 citations · 27 references

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Concepts

Abstract

than non-heparinized DATs. Human bone marrow stromal cells (hBMSCs), when seeded on these VEGF-Hep-DATs, differentiated into endothelial cells which expressed vascular endothelial markers CD34 and VWF, thus resulting in accelerated vascularization of transplanted tissue as compared to the control DAT-only scaffold. In conclusion, these studies demonstrate that VEGF-Hep-DATs promoted greater tissue vascularization as compared to the DAT control scaffold and that VEGF-Hep-DATs are an effective and biocompatible angiogenesis system.

References

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