Romanian Journal of Internal Medicine · 2018 · 16 citations · 24 references
Life SciencesImmunologyPathobiologyAutoimmunityInflammationRheumatologyAntioxidant DefenseDisulfide Bond FormationOxidative StressOxidative Stress In InflammationOxidative Stress MechanismsRheumatoid ArthritisAntioxidant PropertiesControl Group DesignCorrelationDisease Activity MeasurementMatched Control GroupOxidative BiomarkersOxidative Stress In AutoimmunityOxidative Stress Injury
BACKGROUND: Oxidative stress may play an important role in rheumatoid arthritis (RA) etiopathogenesis. The thiol group is a very strong antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with RA by evaluating thiol/disulfide homeostasis. MATERIAL AND METHODS: A total of 50 female RA patients and 50 healthy female controls were included in this study. Thiol and disulfide values were calculated utilizing novel methods. RESULTS: Native thiol (p < 0.001) and total thiol (p < 0.001) levels of RA patients were significantly lower compared to values in the control group. However, the disulfide (p < 0.001) levels of RA patients were strongly higher than in healthy individuals. A negative correlation was found between thiol and disease activity score-28 among the patients, whereas a positive correlation was found between disulfide and disease activity score-28 among the patients. CONCLUSION: We found that the thiol-disulfide rate deteriorated in RA patients, with the proportion of disulfide increasing. There is a strong correlation between the decrease in thiol levels, increase in disulfide levels and the disease activity scores.
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Increased Reactive Oxygen Species Formation and Oxidative Stress in Rheumatoid Arthritis
Somaiya Mateen, Shagufta Moin, Abdul Qayyum Khan et al. · PLoS ONE · 2016 · 427 citations · Full text