Concepedia

Crucial role of RAGE in inappropriate increase of smooth muscle cells from patients with pulmonary arterial hypertension

Kazufumi Nakamura, Masakiyo Sakaguchi, Hiromi Matsubara, Satoshi Akagi, Toshihiro Sarashina, Kentaro Ejiri, Kaoru Akazawa, Megumi Kondo, Koji Nakagawa, Masashi Yoshida,

PLoS ONE · 2018 · 26 citations · 21 references

DOIFull text

Open access

Abstract

RAGE plays a crucial role in the inappropriate increase of PAH-PASMCs. Inhibition of RAGE signaling may be a new therapeutic strategy for PAH.

References

21

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

Michael P. Neeper, Ann Marie Schmidt, J Brett et al. · Journal of Biological Chemistry · 1992 · 1.5K citations · Full text

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Genome-wide association study identifies five loci associated with lung function

Emmanouela Repapi · Nature Genetics · 2009 · 593 citations · Full text

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Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension

Marius M. Hoeper, Robyn J. Barst, Robert C. Bourge et al. · Circulation · 2013 · 549 citations

TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding

Masakiyo Sakaguchi, Hitoshi Murata, Ken-ichi Yamamoto et al. · PLoS ONE · 2011 · 216 citations · Full text

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S100A4/Mts1 Produces Murine Pulmonary Artery Changes Resembling Plexogenic Arteriopathy and Is Increased in Human Plexogenic Arteriopathy

Steven C. Greenway, Robert Jan van Suylen, Gideon Du Marchie Sarvaas et al. · American Journal Of Pathology · 2004 · 137 citations

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