Journal of Cellular Biochemistry · 2018 · 24 citations · 22 references
MedicineCancer BiologyOncologyMetastasisSignal TransductionTumor ProgressionBladder CancerCancer Cell SignalingCancer ProgressionChemokine NetworksChemokine SignalingSignal Transduction In CancerCancer Signaling PathwaysChemokines In MetastasisChemokines In Tumor ProgressionKaplan-meier Survival EstimatesMetastatic Bladder CancerMetastatic SignalingPrognostic Biomarker DiscoveryPrognostic Risk Assessment
As an important chemokine receptor, the role of CCR4 in the progression of bladder cancer (BC) remains unknown. In this study, we have shown that CCR4 expression was upregulated in bladder carcinoma tissues compared with adjacent nontumor tissues. Kaplan-Meier survival analysis revealed that CCR4 expression was an independent prognostic risk factor in BC patients, and the addition of CCL17 induced CCR4 production and promoted migration and invasion of BC cells. In addition, CCR4 knockdown significantly attenuated the migratory and invasive capabilities of BC cells. Mechanistically, CCL17-CCR4 axis is involved in ERK1/2 signaling and could mediate the migration and invasion of BC cells by regulating MMP13 activation. This study suggests that CCR4 might represent a promising prognostic biomarker and a potential therapeutic option for BC.
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Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2018 · 17K citations · Full text
Involvement of chemokine receptors in breast cancer metastasis
Anja Müller, Bernhard Homey, Hortensia Soto et al. · Nature · 2001 · 5.3K citations
Medicine, Cancer Biology, Oncology +14
Raffaella Bonecchi, Paola Panina‐Bordignon, Daniele D’Ambrosio et al. · The Journal of Experimental Medicine · 1998 · 2K citations · Full text