Safflower yellow promotes angiogenesis through p-VHL/ HIF-1α/VEGF signaling pathway in the process of osteogenic differentiation

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

Hans-Peter Gerber, Thiennu H. Vu, Anne Ryan et al. · Nature Medicine · 1999 · 2.1K citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +13

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

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Life Sciences, Biochemistry, Cell Biology +15

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

J E Park, G A Keller, Napoleone Ferrara · Molecular Biology of the Cell · 1993 · 1.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival

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Medicine, Cell Biology, Apoptosis +15

The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development

Ying Wang, Chao Wan, Lianfu Deng et al. · Journal of Clinical Investigation · 2007 · 726 citations · Full text

Medicine, Developmental Biology, Molecular Genetics +17