Integration of micronucleus tests with a gene mutation assay in F344 gpt delta transgenic rats using benzo[a]pyrene

An application of Acridine Orange fluorescent staining to the micronucleus test

Makoto Hayashi, Toshio Sofuni, Morizo Ishidate · Mutation Research Letters · 1983 · 413 citations

Medicine, Cell Biology, Pathology +13

Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice.

Jaime Kapitulnik, Peter G. Wislocki, Wayne Levin et al. · PubMed · 1978 · 240 citations

Medicine, Oncology, Carcinogenesis +13

Other transgenic mutation assays: A new transgenic mouse mutagenesis test system using Spi− and 6-thioguanine selections

T. Nohmi, Masaya Katoh, Hiroshi Suzuki et al. · Environmental and Molecular Mutagenesis · 1996 · 213 citations

Life Sciences, Biotechnology, Genetics +17

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

Dhiren R. Thakker, Haruhiko Yagi, Anthony Y.H. Lu et al. · Proceedings of the National Academy of Sciences · 1976 · 205 citations · Full text

Life Sciences, Biochemistry, Toxicology +15

Metabolism, bioavailability, and toxicokinetics of Benzo(α)pyrenein F-344 rats following oral administration

Aramandla Ramesh, Frank Inyang, Darryl B. Hood et al. · Experimental and Toxicologic Pathology · 2001 · 149 citations

Pharmacy, Pharmacokinetics, Toxicology +13