A Hyperactive Form of the Zinc Cluster Transcription Factor Stb5 Causes <i>YOR1</i> Overexpression and Beauvericin Resistance in Candida albicans

Abstract

Gain-of-function mutations in the zinc cluster transcription factors Mrr1, Tac1, and Upc2, which result in constitutive overexpression of their target genes, are a frequent cause of fluconazole resistance in the pathogenic yeast Candida albicans . In this study, we show that an activated form of another zinc cluster transcription factor, Stb5, confers resistance to the natural compound beauvericin via the overexpression of YOR1 , encoding an efflux pump of the ATP-binding cassette transporter superfamily.