Chemistry & Biodiversity · 2018 · 33 citations · 11 references
Life SciencesImmunologyPharmacologyBiochemical PharmacologyInflammationInnate ImmunityAnti-inflammatory PharmacologyAntioxidant DefenseInflammatory ArthritisOxidative Stress In InflammationPolysaccharide FunctionPolysaccharide PropertiesAnti-inflammatory ActivityAnti-inflammatory Natural ProductsAnti-inflammatory ResponseMalondialdehyde FormationNitric Oxide Synthase RegulationPolysaccharide Natural ProductsSuperoxide Dismutase 1Superoxide Dismutase Function
Abstract Sargentodoxa cuneata decoction has been used to treat arthritis in China for hundreds of years. Herein, the polysaccharide fraction (PSC) purified from S. cuneata was evaluated for its in vitro and in vivo anti‐inflammatory effects. PSC and its sub‐fractions PSCA‐1 and PSCB‐1 significantly suppressed nitric oxide (NO) release in LPS‐induced RAW264.7 cells by down regulating the inducible nitric oxide synthase (iNOS) level. Furthermore, PSC markedly inhibited carrageenan induced rat hind paw edema, decreased in hind paw, serum and liver malondialdehyde (MDA) levels and prostaglandin E 2 (PGE 2 ) levels. In addition, PSC increased superoxide dismutase (SOD) activity in serum and liver of the rats. These results revealed that the polysaccharide obtained from S. cuneata (PSC) possessed potent anti‐inflammatory activity and may be one of the important bioactive constituents from the plant responsible for the anti‐arthritis effect.
11
Inflammation 2010: New Adventures of an Old Flame
Ruslan Medzhitov · Cell · 2010 · 1.8K citations · Full text
Hua‐Bin Li, Chi-Chun Wong, Ka‐Wing Cheng et al. · LWT · 2007 · 541 citations
Seija R. Räisänen, Sari L Alatalo, Hannele Ylipahkala et al. · Biochemical and Biophysical Research Communications · 2005 · 78 citations