ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior

Abstract

These findings confirmed that airway inflammatory induced by ITGB4 deficiency is the important incentive for the BD-like behavior during asthma pathogenesis. The ITGB4-deficient mice provide a validated animal model for us to study the possible mechanism of BD-like psychiatric comorbidity of asthma patients.