Science · 1998 · 1.9K citations · 29 references
MedicineImmunologyMolecular GeneticsImmunogeneticsImmunopathologyInflammationCytokine BiologyRespiratory AllergyAsthma ImmunogeneticsAsthma ModelsAsthma PathophysiologyEosinophil RecruitmentMurine ModelsNeutralizationT Helper Cell CytokinesT-cell Activation By Cytokines
Asthma pathogenesis involves T cell cytokines, with IL‑4 and its receptor shown to contribute in murine models. Neutralizing IL‑13 reduces airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction, and both IL‑13 and IL‑4 can induce an asthma‑like phenotype via the IL‑4 receptor α chain, linking this pathway to asthma genetics.
The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the α chain of the IL-4 receptor, ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction. Administration of either IL-13 or IL-4 conferred an asthma-like phenotype to nonimmunized T cell–deficient mice by an IL-4 receptor α chain–dependent pathway. This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor.
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RAG-1-deficient mice have no mature B and T lymphocytes
Peter Mombaerts, John Iacomini, Randall S. Johnson et al. · Cell · 1992 · 2.9K citations
Life Sciences, Genetics, Immunology +13
lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses
A Minty, Pascale Chalon, Jean‐Marie Derocq et al. · Nature · 1993 · 892 citations