TiO ₂ Nanoparticle Catalyzed Rapid Synthesis of Spiroxindole‐Pyrrolidine in Aqueous Medium and Evaluation of their Antimicrobial Properties

Abstract

Abstract We report TiO 2 nanoparticle as a reusable heterogeneous catalyst for rapid synthesis of Spiroxindole‐Pyrrolidine by reacting of 3‐aryl‐1‐(pyridin‐2‐yl)‐prop‐2‐en‐1‐one, isatins and benzylamines via 1,3‐dipolar cycloaddition reaction using water as reaction media. The reaction proceeded with excellent regio and diastereoselective product formation along with good yields within 30 minutes. Structure of the product was unambiguously confirmed by single crystal X‐ray diffraction study. Synthesized Spiroxindole‐Pyrrolidine derivatives were evaluated for antimicrobial activity and found that all the compounds performed well against standard streptomycin drug.