In Silico Prediction of Major Clearance Pathways of Drugs among 9 Routes with Two-Step Support Vector Machines

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases

Todd Ewing, Shingo Makino, A. Geoffrey Skillman et al. · Journal of Computer-Aided Molecular Design · 2001 · 1.2K citations

Pharmacy, Medicinal Chemistry, Computational Chemistry +15

Biopharmaceutics Classification System: The Scientific Basis for Biowaiver Extensions

Lawrence X. Yu, Gordon L. Amidon, James E. Polli et al. · Pharmaceutical Research · 2002 · 565 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +11

Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)

Manthena V. S. Varma, Stefanus J. Steyn, Charlotte Allerton et al. · Pharmaceutical Research · 2015 · 311 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Physicochemical Determinants of Human Renal Clearance

Manthena V. S. Varma, Bo Feng, R. Scott Obach et al. · Journal of Medicinal Chemistry · 2009 · 209 citations

Pharmacy, Pharmacokinetics, Pharmacology +14