Synthesis of 3,4-diaryl- and 4-acyl-3-arylpyrroles and study of their antimitotic activity

Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

C. Michael Lin, Sheo B. Singh, Ping S. Chu et al. · Molecular Pharmacology · 1988 · 282 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Syntheses and antitumor activity of cis-restricted combretastatins: 5-Membered heterocyclic analogues

Koji Ohsumi, Toshihiro Hatanaka, Koichi Fujita et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 183 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Isoxazole-type derivatives related to combretastatin A-4, synthesis and biological evaluation

Julia Kaffy, Renée Pontikis, Danièle Carrez et al. · Bioorganic & Medicinal Chemistry · 2006 · 132 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays

Alex S. Kiselyov, Marina N. Semenova, Natalya B. Chernyshova et al. · European Journal of Medicinal Chemistry · 2010 · 79 citations

Life Sciences, Cell Biology, Pharmacology +17

Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines

Dmitry V. Demchuk, A. V. Samet, Vladimir I. Ushkarov et al. · Bioorganic & Medicinal Chemistry · 2013 · 77 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9