Hypoxic tumor therapy by hemoglobin-mediated drug delivery and reversal of hypoxia-induced chemoresistance

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

Acid pH in tumors and its potential for therapeutic exploitation.

Ian F. Tannock, Daniela Rotin · PubMed · 1989 · 1.6K citations

Medicine, Oncology, Pharmacology +16

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

Gabriel Helmlinger, Fan Yuan, Marc Dellian · Nature Medicine · 1997 · 1.6K citations

Medicine, Cancer Biology, Oncology +9

Intelligent Albumin–MnO₂ Nanoparticles as pH‐/H₂O₂‐Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

Qian Chen, Liangzhu Feng, Jingjing Liu et al. · Advanced Materials · 2016 · 1K citations

Pharmacy, Oncology, Pharmaceutics +17

Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.

Katrina M. Comerford, Timothy J. Wallace, Jörn Karhausen et al. · PubMed · 2002 · 844 citations

Medicine, Oncology, Pharmacology +16