TBX18 transcription factor overexpression in human‐induced pluripotent stem cells increases their differentiation into pacemaker‐like cells

Abstract

It was demonstrated that the TBX18 gene is able to conduct hiPSCs to differentiate into pacemaker-like cells. The TBX18 gene delivery seems to have the potential for the development of biological pacemakers; however, more investigations are still needed to assess its usefulness to fix arrhythmic conditions with SAN failure basis.