Concepedia

The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling

Zhenjie Zhang, Samuele Marro, Yingsha Zhang, Kristin L. Arendt, Christopher Patzke, Bo Zhou, Tyler Fair, Nan Yang, Thomas C. Südhof, Marius Wernig,

Science Translational Medicine · 2018 · 122 citations · 72 references

DOI

Concepts

Abstract

mutations that might contribute to neuronal dysfunction in FXS. In addition, our results suggest that FXS patient iPS cell-derived neurons might be useful for studying the mechanisms mediating functional abnormalities in FXS.

References

72

High-efficiency transformation of mammalian cells by plasmid DNA.

C Chen, Hiroto Okayama · Molecular and Cellular Biology · 1987 · 5.3K citations · Full text

, , +13

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

Stuart M. Chambers, Christopher A. Fasano, Eirini P. Papapetrou et al. · Nature Biotechnology · 2009 · 3.7K citations · Full text

, , +13

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

Annemieke J.M.H. Verkerk, Maura Pieretti, James S. Sutcliffe et al. · Cell · 1991 · 3.5K citations

, , +12

A decade of molecular biology of retinoic acid receptors

Pierre Chambon · The FASEB Journal · 1996 · 2.9K citations

, , +16

Activity-dependent scaling of quantal amplitude in neocortical neurons

Gina G. Turrigiano, Kenneth R. Leslie, Niraj S. Desai et al. · Nature · 1998 · 2.3K citations

, , +16