Concepedia

Clinically-Relevant Rapamycin Treatment Regimens Enhance CD8<sup>+</sup>Effector Memory T Cell Function In The Skin and Allow their Infiltration into Cutaneous Squamous Cell Carcinoma

Ji‐Won Jung, Margaret Veitch, Jennifer A. Bridge, Nana Haahr Overgaard, Jazmina L. Gonzalez Cruz, Richard Linedale, Michael E. Franklin, Nicholas A. Saunders, Fiona Simpson, Ian H. Frazer,

OncoImmunology · 2018 · 50 citations · 43 references

DOIFull text

Open access

Concepts

Abstract

SSC formation and regression of pre-existing premalignant lesions.

References

43

mTOR regulates memory CD8 T-cell differentiation

Koichi Araki, Alexandra P. Turner, Virginia Shaffer et al. · Nature · 2009 · 1.6K citations · Full text

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Sirolimus for Kaposi's Sarcoma in Renal-Transplant Recipients

Giovanni Stallone, Antonio Schena, Barbara Infante et al. · New England Journal of Medicine · 2005 · 984 citations · Full text

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Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

Yongsheng Li, Li X, Xin Xiao Zheng et al. · Nature Medicine · 1999 · 750 citations

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The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

Rajesh R. Rao, Qingsheng Li, Kunle Odunsi et al. · Immunity · 2010 · 634 citations · Full text

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T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

Laura K. Mackay, Erica Wynne-Jones, David Freestone et al. · Immunity · 2015 · 601 citations · Full text

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