Domino Corey–Chaykovsky Reaction for One-Pot Access to Spirocyclopropyl Oxindoles

Abstract

The development of the sequential Corey-Chaykovsky reactions of isatins, spiroepoxy-, or spiroaziridine oxindoles with sulfur ylide has led to the discovery of a unique reaction mode that allows easy and direct one-pot access to a range of spirocyclopropyl oxindoles.