Exendin-4 promotes the vascular smooth muscle cell re-differentiation through AMPK/SIRT1/FOXO3a signaling pathways

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Carles Cantó, Zachary Gerhart‐Hines, Jérôme N. Feige et al. · Nature · 2009 · 3.2K citations · Full text

Life Sciences, Biochemistry, Cell Biology +15

Dipeptidyl‐peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon‐like peptide‐1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serum

Rolf Mentlein, Baptist Gallwitz, Wolfgang E. Schmidt · European Journal of Biochemistry · 1993 · 1.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

Timothy J. Kieffer, Christopher H.S. McIntosh, Raymond A. Pederson · Endocrinology · 1995 · 1.1K citations

Life Sciences, Biochemistry, Endocrinology +17

SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase

Ilwola Mattagajasingh, Cuk‐Seong Kim, Asma Naqvi et al. · Proceedings of the National Academy of Sciences · 2007 · 870 citations · Full text

Life Sciences, Biochemistry, Physiology +14

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

Rüdiger Göke, H. C. Fehmann, Thomas Linn et al. · Journal of Biological Chemistry · 1993 · 838 citations · Full text

Life Sciences, Endocrinology, Pharmacology +17