Christopher H.S. McIntosh

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

Timothy J. Kieffer, Christopher H.S. McIntosh, Raymond A. Pederson · Endocrinology · 1995 · 1.1K citations

Life Sciences, Biochemistry, Endocrinology +17

Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats

J. Andrew Pospisilik, Jennifer Martin, Timothy Doty et al. · Diabetes · 2003 · 334 citations · Full text

Medicine, Endocrinology, Pharmacology +15

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

Luan Shu, Aleksey V. Matveyenko, Julie Kerr‐Conte et al. · Human Molecular Genetics · 2009 · 274 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +17

Improved Glucose Tolerance in Zucker Fatty Rats by Oral Administration of the Dipeptidyl Peptidase IV Inhibitor Isoleucine Thiazolidide

Raymond A. Pederson, Heather A. White, Dagmar Schlenzig et al. · Diabetes · 1998 · 261 citations

Medicine, Endocrinology, Pharmacology +16

Glucose-dependent Insulinotropic Polypeptide (GIP) Stimulation of Pancreatic β-Cell Survival Is Dependent upon Phosphatidylinositol 3-Kinase (PI3K)/Protein Kinase B (PKB) Signaling, Inactivation of the Forkhead Transcription Factor Foxo1, and Down-regulation of bax Expression

Sujin Kim, Kyle D. Winter, Cuilan Nian et al. · Journal of Biological Chemistry · 2005 · 241 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15