The impact of <em>ABCB1</em> (rs1045642 and rs4148738) and <em>CES1</em> (rs2244613) gene polymorphisms on dabigatran equilibrium peak concentration in patients after total knee arthroplasty

Abstract

Our findings indicate that the polymorphisms of <i>ABCB1</i> rs1045642 may have a prominent contribution to the safety of dabigatran in patients after knee surgery. Moreover, TT genotype may be associated with the higher risk of hemorrhagic complications in this population. There were no influence of polymorphism of <i>ABCB1</i> rs4148738 and <i>CES1</i> rs2244613 on dabigatran peak and through concentrations. Larger studies are needed to confirm our observations.